Deborah Muoio

George Barth Geller Distinguished Professor of Cardiovascular Disease

Deb Muoio is Professor in the Departments of Medicine and Pharmacology & Cancer Biology at Duke University, and Director of Basic Science Research at the Duke Molecular Physiology Institute (DMPI). Projects in her laboratory focus on metabolic networks that control muscle and whole-body energy metabolism, with emphasis on mechanisms linking obesity, aging and physical inactivity to mitochondrial dysfunction, insulin resistance and cardiometabolic disease. During the past 15 years, her team has worked closely with the Metabolomics and Biomarkers Core Laboratory at the DMPI to develop and apply mass spectrometry-based molecular profiling tools for metabolic research. She also led efforts to launch new programs at the DMPI in proteomics and metabolic flux analysis. To complement these powerful molecular profiling tools, her laboratory has developed a sophisticated platform for comprehensive assessment of mitochondrial bioenergetics and energy transduction.Her team is integrating this new platform with mass spectrometry-based metabolomics, proteomics and metabolic flux analysis to gain insights into mechanisms by which mitochondria modulate insulin action and cardiometabolic health. Dr. Muoio’s laboratory has enjoyed longstanding support from the NIDDK and NHLBI.